Commercial airlines around the world on Monday were weighing how long to suspend Middle East flights as a conflict which has already cut off major flight routes entered a new phase after the U.S. attacked key Iranian nuclear sites and Tehran vowed to defend itself.

Malaysians and a Singaporean, arrived at the Kuala Lumpur International Airport (KLIA) on Sunday (Jun 22) night after being evacuated from Iran.

The Philippines expressed deep concern over the latest security developments in the Middle East, calling for restraint and diplomacy amid fears of escalating conflict involving Iran, Israel, and the United States (US).

Iran’s leaders are discovering they’re on their own against the U.S. and Israel, without the network of proxies and allies that allowed them to project power in the Middle East and beyond.

Domestic political concerns, as well as tough losses suffered in nearly two years of regional conflicts and upheavals, appear to have led these Iran allies to take a back seat in the latest round convulsing the region.

The U.S. strikes came after a week of open conflict between Israel and Iran, sparked by Israel’s sudden barrage of attacks against Iran’s nuclear and military structure. Israeli strikes began on June 13.