Hundreds of civilians, mostly in Iran, have been killed by dueling airstrikes despite international pleas for de-escalation.

Israel's strikes on Iran have targeted several of its nuclear facilities, as it claims the Islamic Republic seeks to develop nuclear weapons.

Investors have been weighing the odds of further escalation in the conflict and spillover into the broader oil-rich Middle East.

Israel launched blistering attacks on the heart of Iran's nuclear and military structure Friday, deploying warplanes and drones previously smuggled into the country to attack key facilities and kill top generals and scientists -- a barrage it said was necessary before its adversary got any closer to building an atomic weapon.